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Critical limb ischemia is the end stage of peripheral arterial disease, mostly presenting as severe limb pain. Its greatest significance lies within the fact that it often leads to limb loss in a very short period of time. The aim of this thesis is to review existing data on critical limb ischemia. It is composed of several chapters, each discussing different key features of the disease.

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The introductory chapter provides the definition of critical limb ischemia and general concerns on this topic. Chapter two gives a brief review of current epidemiological facts and risk factors contributing to development of the disease, while the third chapter deals with pathophysiological key points of this state. Furthermore, the fourth chapter revises clinical presentations of critical limb ischemia and the fifth chapter discusses possibile options when it comes to diagnostics of the disease.The classification of peripheral arterial disease and critical limb ischemia is reviewed in chapter 6. The latest options in treatment of this state, both surgical and pharmacological, are shown in the fifth chapter, as well as some new treating options such as therapeutic angiogenesis. Differential diagnosis and prognosis are briefly revised in the sixth and seventh chapter. Finally, the last chapter – the conclusion – summarizes key points of all previous chapters, pointing out latest discoveries regarding critical limb ischemia.